Optimizing Size and Copy Number For PEG-fMLF (N-Formyl-methionyl-leucyl-phenylalanine) Nanocarrier Uptake by Macrophages
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چکیده
منابع مشابه
Regulation of N-.formyl-methionyl-leucyl-phenylalanine
Neutrophil responses to a-N-formyl-LMetL-Leu-L-Phe (IMLF) are modulated by inhibitors of surface membrane neutral endopeptidase (NEP), such as phosphoramidon (PPAD). Because receptor recycling is presumably required for a sustained cellular response, the effect of PPAD on receptor reexpression was examined. After down-regulation of surface fMLF receptors by IMLF, PPAD blocked the normal reexpre...
متن کاملEffect of inhaled formyl-methionyl-leucyl-phenylalanine on airway function.
Formyl-methionyl-leucyl-phenylalanine (FMLP), a synthetic, acylated tripeptide analogous to bacterial chemotactic factors, has been shown to cause bronchoconstriction in guinea pig, rabbit, and human airways in vitro. To determine whether FMLP causes bronchoconstriction in man in vivo, a preliminary study was undertaken in which five non-smokers (mean age 35 years, FEV1 94% (SEM 5%) predicted) ...
متن کاملCarcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine
Carcinoembryonic antigen (CEA) is a surface glycoprotein expressed in human epithelial cells and is released from their surface, especially during colorectal cancer. Frequently, colorectal cancer is accompanied by inflammation, where tumor-infiltrating neutrophils play an important role. CEA was also found to be a strong chemotactic agent for neutrophils. The purpose of this study was to find o...
متن کاملCigarette smoking increases neutrophil formyl methionyl leucyl phenylalanine receptor numbers.
STUDY OBJECTIVES The purpose of this study was to explore the relationship between cigarette smoking and COPD on the number of formyl methionyl leucyl phenylalanine (FMLP) receptors on peripheral neutrophils. DESIGN AND PARTICIPANTS Three groups of subjects were studied: subjects with COPD (n = 13), healthy smokers (n = 6), and healthy nonsmokers (n = 6). INTERVENTIONS Fifty milliliters of ...
متن کاملStandard Thermodynamic Functions of Tripeptides N-Formyl-l-methionyl-l-leucyl-l-phenylalaninol and N-Formyl-l-methionyl-l-leucyl-l-phenylalanine Methyl Ester
The heat capacities of tripeptides N-formyl-l-methionyl-l-leucyl-l-phenylalaninol (N-f-MLF-OH) and N-formyl-l-methionyl-l-leucyl-l-phenylalanine methyl ester (N-f-MLF-OMe) were measured by precision adiabatic vacuum calorimetry over the temperature range from T = (6 to 350) K. The tripeptides were stable over this temperature range, and no phase change, transformation, association, or thermal d...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2007
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc070066k